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Trospium, an incontinence drug, could have an additional topical effect on the bladder


A commonly prescribed incontinence drug may help patients in more than one way, according to research carried out at University of Pittsburgh.

When taken orally, Trospium chloride ( Sanctura ) not only helps control symptoms of overactive bladder systemically, it also may help control symptoms in the bladder itself when it comes into contact with the bladder walls.

" When taken orally, certain classes of drugs can control the muscle contractions that cause conditions like overactive bladder. In this study, we have found one drug, Trospium, reacts with the bladder muscle as urine is stored in the bladder, " said Michael Chancellor, of University of Pittsburgh School of Medicine.

In the study, urine samples from human subjects taking the anti-muscarinic drugs Trospium, Tolterodine LA and Oxybutynin XL and from control subjects were instilled into the bladders of animal models.

Researchers induced bladder overactivity using cCarbachol.

The Trospium bladder did not react to the Carbachol, indicating that the Trospium had a topical effect on controlling the muscle contractions.
In the control, Tolterodine- and Oxybutynin-treated bladders, the length of time between bladder contractions and the bladder's capacity were decreased – representing overactive bladder-type conditions and indicating no topical effect.

Anti-muscarinic drugs block receptors in the bladder responsible for smooth muscle contractions; by easing the muscle contractions, the number of incontinence episodes are reduced and bladder capacity is increased.
Common urologic conditions like overactive bladder are caused by involuntary contractions of the detrusor muscle, which controls the bladder.

More than 17 million Americans suffer from overactive bladder, a condition that significantly affects the patient's quality of life. An estimated 80 percent of these patients do not seek help or treatment for this condition. Overactive bladder is characterized by the following conditions: frequency – urinating more than eight times in a 24 hour period; urgency – the immediate and strong urge to urinate; and urge incontinence – the inability to suppress urgency, resulting in the leaking or loss of urine.

Source: 100th Annual Meeting of the American Urological Association ( AUA ), 2005

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